In many universes, Doc Ock is involved with the origin of Spidey. Introduced in Ultimate Spider-Man #2 (2000) by Brian Michael Bendis and Mark Bagley, Dr. Octavius was a scientist working for Oscorp on the Oz formula, an attempt to recreate the Super-Soldier formula. He would help Osborn steal Peter Parker’s DNA and used it on Osborn transforming Osborn into the Green Goblin monster. In the result explosion his tentacles were fused to his body. He would use these to attack Justin Hammer, who he was a corporate spy for and blamed for his condition. Spider-man intervened but Justin Hammer died of a heart attack.

Ock was taken into custody by SHIELD but escaped with Osborn and other Spidey villains. They forced Spidey to join them by threatening his aunt, but they were stopped by the Ultimates. He would later learn his ex-wife sold his likeness to Hollywood and he would attack the film crew filming the Spider-man movie. (Yes, it was an attempt to advertise the second Raimi movie.) He later uses Peter’s DNA and creates five clones alongside Ben Reilly (who in this universe isn’t Spidey’s clone). He would be hired by Roxxon and became their head or research. They would capture Spider-woman. He would be defeated by Spider-man but would later escape with Goblin, only to be killed by said villain.

During the Ultimate universe push by Marvel, he would receive a figure in the Toybiz Spider-man Classics Series 15 but it has some action feature for kids.

Universe: Ultimate Universe (Earth-1610)